DOI: 10.1007/s00259-016-3561-8Pages: 500-508

Utility of 18F-fluoroestradiol (18F-FES) PET/CT imaging as a pharmacodynamic marker in patients with refractory estrogen receptor-positive solid tumors receiving Z-endoxifen therapy

1. National Cancer Institute, NIH, Cancer Imaging Program

2. National Cancer Institute, Molecular Imaging Program

3. National Cancer Institute, Division of Cancer Treatment and Diagnosis and Center for Cancer Research

4. National Cancer Institute, NIH, Biometric Research Program

5. Leidos Biomedical Research, Inc., Clinical Research Directorate/Clinical Monitoring Research Program

6. Leidos Biomedical Research, Frederick National Laboratory for Cancer Research

7. National Cancer Institute, Early Clinical Trials Development Program, DCTD

Correspondence to:
Frank I. Lin
Tel: 301-496-7776
Email: frank.lin2@nih.gov

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Abstract

Background

Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because it bypasses potential drug resistance mechanisms attributable to patient variability in the expression of the hepatic microsomal enzyme CYP2D6. 18F-FES is a positron emission tomography (PET) imaging agent which selectively binds to estrogen receptor alpha (ER-α) and has been used for non-invasive in vivo assessment of ER activity in tumors. This study utilizes 18F-FES PET imaging as a pharmacodynamic biomarker in patients with ER+ tumors treated with Z-endoxifen.

Methods

Fifteen patients were recruited from a parent therapeutic trial of Z-endoxifen and underwent imaging with 18F-FES PET at baseline. Eight had positive lesions on the baseline scan and underwent follow-up imaging with 18F-FES 1–5 days post administration of Z-endoxifen.

Results

Statistically significant changes (p = 0.0078) in standard uptake value (SUV)-Max were observed between the baseline and follow-up scans as early as 1 day post drug administration.

Conclusion

F-FES PET imaging could serve as a pharmacodynamic biomarker for patients treated with ER-directed therapy.

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  • Accepted: Oct 25, 2016
  • Online: Nov 21, 2016

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