DOI: 10.1007/s00259-016-3590-3Pages: 1-9

Central noradrenaline transporter availability in highly obese, non-depressed individuals

1. University of Leipzig, Department of Nuclear Medicine

2. Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases

3. Max Planck Institute for Human Cognitive and Brain Sciences

4. University of Leipzig, Day Clinic for Cognitive Neurology

5. University of Leipzig, Department of Neuroradiology

6. University of Cambridge, Department of Psychiatry and Behavioural and Clinical Neuroscience Institute

7. University of Leipzig, Department of Internal Medicine

8. University of Leipzig, Department of Medical Psychology and Medical Sociology

9. New York University School of Medicine, Departments of Radiology and Psychiatry

Correspondence to:
Swen Hesse
Email: swen.hesse@medizin.uni-leipzig.de

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Abstract

Purpose

The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate.

Methods

We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[11C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m2), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m2) healthy controls.

Results

Overall, we found no significant differences in binding potential (BPND) values between obese and non-obese individuals in the investigated brain regions, including the NAT-rich thalamus (0.40 ± 0.14 vs. 0.41 ± 0.18; p = 0.84) though additional discriminant analysis correctly identified individual group affiliation based on regional BPND in all but one (control) case. Furthermore, inter-regional correlation analyses indicated different BPND patterns between both groups but this did not survive testing for multiple comparions.

Conclusions

Our data do not find an overall involvement of NAT changes in human obesity. However, preliminary secondary findings of distinct regional and associative patterns warrant further investigation.

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  • Accepted: Nov 28, 2016
  • Online: Jan 9, 2017

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