DOI: 10.1007/s00259-017-3824-zPages: 1-9

A score combining baseline neutrophilia and primary tumor SUVpeak measured from FDG PET is associated with outcome in locally advanced cervical cancer

1. Gustave Roussy Cancer Campus, Radiation Oncology Department

2. INSERM, U1030

3. Université Paris-Saclay, Univ Paris Sud

4. Gustave Roussy, Université Paris-Saclay, Department of Medical Physics

5. Université Paris-Saclay, CEA-SHFJ, IMIV, CEA, Inserm, CNRS, Univ. Paris-Sud

6. Gustave Roussy, Université Paris-Saclay, Department of Nuclear Medicine and Endocrine Oncology

7. INSERM, U1015

Correspondence to:
Charlotte Robert
Tel: +33 1 42 11 56 06
Email: ch.robert@gustaveroussy.fr

Close

Abstract

Purpose

We investigated whether a score combining baseline neutrophilia and a PET biomarker could predict outcome in patients with locally advanced cervical cancer (LACC).

Methods

Patients homogeneously treated with definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT) between 2006 and 2013 were analyzed retrospectively. We divided patients into two groups depending on the PET device used: a training set (TS) and a validation set (VS). Primary tumors were semi-automatically delineated on PET images, and 11 radiomics features were calculated (LIFEx software). A PET radiomic index was selected using the time-dependent area under the curve (td-AUC) for 3-year local control (LC). We defined the neutrophil SUV grade (NSG = 0, 1 or 2) score as the number of risk factors among (i) neutrophilia (neutrophil count >7 G/L) and (ii) high risk defined from the PET radiomic index. The NSG prognostic value was evaluated for LC and overall survival (OS).

Results

Data from 108 patients were analyzed. Estimated 3-year LC was 72% in the TS (n = 69) and 65% in the VS (n = 39). In the TS, SUVpeak was selected as the most LC-predictive biomarker (td-AUC = 0.75), and was independent from neutrophilia (p = 0.119). Neutrophilia (HR = 2.6), high-risk SUVpeak (SUVpeak > 10, HR = 4.4) and NSG = 2 (HR = 9.2) were associated with low probability of LC in TS. In multivariate analysis, NSG = 2 was independently associated with low probability of LC (HR = 7.5, p < 0.001) and OS (HR = 5.8, p = 0.001) in the TS. Results obtained in the VS (HR = 5.2 for OS and 3.5 for LC, p < 0.02) were promising.

Conclusion

This innovative scoring approach combining baseline neutrophilia and a PET biomarker provides an independent prognostic factor to consider for further clinical investigations.

To access the full text, please Sign in

If you have institutional access, please click here

  • Accepted: Aug 31, 2017
  • Online: Sep 15, 2017

Article Tools

eanm
EJNMMI Ad