DOI: 10.1007/s00259-017-3927-6Pages: 582-584

One-step synthesis of an 18F-labeled boron-derived methionine analog: a substitute for 11C-methionine?

1. Huazhong University of Science and Technology, Department of Nuclear Medicine, Union Hospital, Tongji Medical College

2. Huazhong University of Science and Technology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College

3. University of Wisconsin – Madison, Department of Medical Physics

4. University of Wisconsin – Madison, Department of Radiology

5. University of Wisconsin – Madison, Carbone Cancer Center

Correspondence to:
Xiaoli Lan
Tel: +86-27-83692633
Email: LXL730724@hotmail.com

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Abstract

Amino acid-based tracers have been extensively investigated for positron emission tomography (PET) imaging of brain tumors, and 11C-methionine (11C-MET) is one of the most extensively investigated. However, widespread clinical use of 11C-MET is challenging due to the short half-life of 11C and low radiolabeling yield. In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, Yang and colleagues report an 18F-labeled boron-derived methionine analog, 18F-B-MET, as a potential substitute for 11C-MET in PET imaging of glioma. The push-button synthesis, highly efficient radiolabeling, and good imaging performance in glioma models make this tracer a promising candidate for future clinical translation.

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  • Accepted: Dec 28, 2017
  • Online: Jan 18, 2018

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