DOI: 10.1007/s00259-018-3976-5Pages: 1405-1416

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

1. National Center of Neurology and Psychiatry, Integrative Brain Imaging Center

2. National Center Hospital of Neurology and Psychiatry, Department of Neurology

3. Nakamura Memorial Hospital, Department of Neurology

4. Nakamura Memorial Hospital, Department of Radiology

5. Fujita Health University, Department of Radiology

6. Tohoku University, Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer

7. Nippon Medical School, Department of Neurology, Graduate School of Medicine

8. Nippon Medical School, Department of Neuropsychiatry, Graduate School of Medicine

9. Showa University, Department of Neurology

10. Kobe University, Department of Radiology

11. National Cerebral and Cardiovascular Center, Department of Radiology

12. Chiba University, Department of Neurology

13. National Center Hospital of Neurology and Psychiatry, Department of Radiology

14. Osaka University, Department of Nuclear Medicine

15. Kyoto University, Department of Neurology

Correspondence to:
Hiroshi Matsuda
Tel: +81-042-341-2712 (2171)
Email: matsudah@ncnp.go.jp

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Abstract

Purpose

The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan.

Methods

This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom.

Results

The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group.

Conclusions

This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.

This article is freely available, click here to access the full text/PDF

  • Accepted: Feb 12, 2018
  • Online: Feb 24, 2018

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