DOI: 10.1007/s00259-018-4153-6Pages: 1-18

Dynamic whole-body PET imaging: principles, potentials and applications

1. Johns Hopkins University, Department of Radiology and Radiological Science

2. University of British Columbia, Departments of Radiology and Physics & Astronomy

3. Weill Cornell Medical College, Department of Radiology

4. Siemens Healthineers

5. University of Wisconsin, Department of Radiology

6. Geneva University Hospital, Division of Nuclear Medicine and Molecular Imaging

7. Washington University School of Medicine, Mallinckrodt Institute of Radiology

Correspondence to:
Arman Rahmim
Email: arahmim1@jhmi.edu

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Abstract

Purpose

In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in relation to conventional standard uptake value (SUV) imaging.

Background

DWB PET involves dynamic data acquisition over an extended axial range, capturing tracer kinetic information that is not available with conventional static acquisition protocols. The method can be performed within reasonable clinical imaging times, and enables generation of multiple types of PET images with complementary information in a single imaging session. Importantly, DWB PET can be used to produce multi-parametric images of (i) Patlak slope (influx rate) and (ii) intercept (referred to sometimes as “distribution volume”), while also providing (iii) a conventional ‘SUV-equivalent’ image for certain protocols.

Results

We provide an overview of ongoing efforts (primarily focused on FDG PET) and discuss potential clinically relevant applications.

Conclusion

Overall, the framework of DWB imaging [applicable to both PET/CT(computed tomography) and PET/MRI (magnetic resonance imaging)] generates quantitative measures that may add significant value to conventional SUV image-derived measures, with limited pitfalls as we also discuss in this work.

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  • Accepted: Aug 28, 2018
  • Online: Sep 29, 2018

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