DOI: 10.1186/s13550-018-0406-4Pages: 1-4

Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans

1. National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Department of Functional Brain Imaging Research

2. National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Department of Radiopharmaceuticals Development

3. Graduate School of Medicine, Kyoto University, Department of Psychiatry

Correspondence to:
Makiko Yamada
Tel: +81-43-206-3251
Email: yamada.makiko@qst.go.jp

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Abstract

Background

The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working memory. However, the role of prefrontal H3 receptors in working memory has not yet been clarified. Therefore, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) techniques, we aimed to investigate the association between the neural activity of working memory and the density of H3 receptors in the prefrontal cortex.

Findings

Ten healthy volunteers underwent both fMRI and PET scans. The N-back task was used to assess the neural activities related to working memory. H3 receptor density was measured with the selective PET radioligand [11C] TASP457. The neural activity of the right dorsolateral prefrontal cortex during the performance of the N-back task was negatively correlated with the density of H3 receptors in this region.

Conclusions

Higher neural activity of working memory was associated with lower H3 receptor density in the right dorsolateral prefrontal cortex. This finding elucidates the role of H3 receptors in working memory and indicates the potential of H3 receptors as a therapeutic target for the cognitive impairments associated with neuropsychiatric disorders.

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  • Accepted: Jun 1, 2018
  • Online: Jun 14, 2018

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