DOI: 10.1186/s13550-018-0417-1Pages: 1-8

Visualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography

1. Chang Gung Memorial Hospital, Department of Neurology

2. Chang Gung University, College of Medicine

3. Taipei Medical University, Graduate Institute of Humanities in Medicine and Research Center for Brain and Consciousness

4. Chang Gung Memorial Hospital, Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation

5. Chang Gung University, Healthy Aging Research Center and Department of Medical Imaging and Radiological Sciences

6. Chang Gung Memorial Hospital, Department of Radiology

7. Chang Gung University, Graduate Institute of Behavioral Sciences

8. Tohoku University, Division of Neuro-imaging, Institute of Development, Aging and Cancer

9. Tohoku Medical and Pharmaceutical University, Department of Pharmacology, Faculty of Medicine

Correspondence to:
Tsong-Hai Lee
Tel: +886 3 328 1200
Email: thlee@adm.cgmh.org.tw

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Abstract

Background

The 18F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, 18F-THK-5351 can also monitor neuroinflammatory process due to high affinity to astrogliosis. We aimed to explore 18F-THK-5351 distribution patterns and characteristics in patients with recent ischemic stroke.

Results

Fifteen patients received 18F-THK-5351 positron emission tomography (PET) and diffusion tensor imaging (DTI) approximately 3 months after ischemic stroke. A region of interest (ROI) was placed in the peri-ischemic area and was mirrored on the contralateral side as the control, and a proportional value was derived from the ratio of the peri-ischemic ROI value over the mirrored ROI value. Increased 18F-THK-5351 retention was observed in the areas around and remote from the stroke location. The proportional 18F-THK-5351 values were negatively correlated with the proportional fractional anisotropy values (r = − 0.39, P = 0.04).

Conclusion

18F-THK-5351 PET imaging provides a potential tool for in vivo visualization of the widespread ischemia-related changes associated with a microstructural disruption in recent ischemic stroke patients.

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  • Accepted: Jun 27, 2018
  • Online: Jul 16, 2018

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