DOI: 10.1186/s13550-018-0432-2Pages: 1-5

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

1. VU University Medical Center, Departments of Radiology & Nuclear Medicine

2. VU University Medical Center, Neurology & Alzheimer Center

3. VU University Medical Center, Anaesthesiology, Amsterdam Neuroscience

4. Lund University, Clinical Memory Research Unit

5. Institutes of Neurology & Healthcare Engineering, UCL

Correspondence to:
Sandeep S. V. Golla
Tel: +31(0)611767523
Email: s.golla@vumc.nl

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Abstract

Background

Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC).

Methods

PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used.

Results

For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05).

Conclusion

PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.

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  • Accepted: Aug 6, 2018
  • Online: Aug 15, 2018

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