DOI: 10.1186/s41181-018-0038-zPages: 1-25

Production of novel diagnostic radionuclides in small medical cyclotrons

1. Radboudumc, Radboud Translational Medicine B.V

2. Radboudumc, Dept. of Radiology and Nuclear Medicine

Correspondence to:
Lars Rutger Perk



The global network of cyclotrons has expanded rapidly over the last decade. The bulk of its industrial potential is composed of small medical cyclotrons with a proton energy below 20 MeV for radionuclides production. This review focuses on the recent developments of novel medical radionuclides produced by cyclotrons in the energy range of 3 MeV to 20 MeV. The production of the following medical radionuclides will be described based on available literature sources: Tc-99 m, I-123, I-124, Zr-89, Cu-64, Ga-67, Ga-68, In-111, Y-86 and Sc-44. Remarkable developments in the production process have been observed in only some cases. More research is needed to make novel radionuclide cyclotron production available for the medical industry.

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  • Accepted: Jan 24, 2018
  • Online: Feb 20, 2018

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